线粒体呼吸链膜蛋白复合体的结构 - 生命科学.pdf

20 4 Vol. 20, No. 4 2008 8 Chinese Bulletin of Life Sciences Aug., 2008 1004-0374(2008)04-0566-13 1 100101 2 100086 () (IIIIIIIV)I/II III III IV c V ATP ( )ATP I II III IV N A D H c c Q244 Q518.3 A Structure of mitochondrial respiratory membrane protein complexes 1 1 1 1 2 SUN Fei *, ZHOU Qiang-jun , SUN Ji , ZHAI Yu-jia , RAO Zi-he (1 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; 2 Tsinghua-Nankai-IBP Joint Research Group for Structural Biology, Tsinghua University, Beijing 100086, China) Abstract: As the important energy factory of eukaryotic cells, mitochondrion is the place for cellular respiration that includes citric acid cycle and oxidative phosphorylation process (OXPHOS). The OXPHOS electron transfer chain (mitochondrial respiration chain) is located on the inner membrane of mitochondrion and comprising of four large trans-membrane protein complexes (mitochondrial respiratory Complex I, II, III and IV) as well as ubiquinone between Complex I/II and III and cytochrome c between Complex III and IV. The function of mitochondrial respiration chain is biological oxidation which is coupled with phosphorylation by ATP syn- thesis enzyme (ATPase, called Complex V) and then complete OXPHOS prod