PPARγ在垂体腺瘤组织中的表达及意义.pdfVIP

一 8O 一 2008。v0l 12．No．1 文章编号：1007—4287(2008)01—0080—03 PPAR7在垂体腺瘤组织中的表达及意义 陶帮宝 ，郭新宾 ，卞留贯 ，孙青芳 ，杨 明 周岩方 ，牟朝辉 (1．台州市第一人民医院神经外科，浙江台州318020； 2．天津医科大学总医院神经外科，天津300052；3．上海瑞金医院神经外科，上海20o025) 摘要：目的 探讨过氧化物酶增生物殖体激活受体7(PP )在垂体腺瘤中的表达及意义。方法 收集27例垂 体腺瘤标本，通过Western blot方法，从蛋白水平检测PPAR7在27例垂体腺瘤、3例正常垂体组织、2例胶质细胞瘤中 的表达。结果 PPAR7在所有垂体肿瘤组织中都有丰富表达，其表达显著高于正常垂体组织(P0．01)，在非侵袭性 腺瘤和侵袭性腺瘤中的表达量分别为0．56±0．31，1．02±0．28，两者之间有显著差异(P0．01)。结论 PPAR7的表 达与肿瘤大小及侵袭程度相关，表明PPAR7的表达与肿瘤的发生、发展密切相关，检测PPAR7有可能预测垂体腺瘤预 后的重要指标。 关键词：PPAR7；垂体腺瘤；Western blot；侵袭 中图分类号：R739．41 文献标识码：A The expresion and significance ofperoxisome proliferator-activated receptor-?(PPAR-?)in#tuUary adenon~ TAO bao，GUO X~-bln，BIAN l~-guan，et ．(Department of neurosurgery，Central hosp~ ， province Taizhou嘶 ，Taizhou 318020) Abstract：Objective T 0 investigate the expression and siguificance of pemx／some prolifemtors acfived receptor-7in pituitary adenomas(PPAR-y)．Methods 27pituitary adenomas were collected immediately after transsphenoidal surgery．Western blot analy— sis were performed to determine the expression ofPPAR-y protein in 27 pituitary adenomases，3 normal pituitary and2 slioma．Results The expression ofPPARy in all pituitary adenomases was observed to be strongerthan that in normal#tuitary by Westerblot analy- sis(P0．01)，in addition，The expression of PPARy in invasive group and non-invasive group was 0．56±0．31，1．02±0．28，re— spective~，and there Was significant different(P0．01)．Conclusion The results reveal that what were relation of occurring and development contributing to the invasion of#tuitary adenomas，it may be useful to forecast development of#tuitary adenomas by ex— amine Key words：PPAR·y；pituitary adenomas；Western blot；invasion