甘氨双唑钠对食管癌放射治疗增敏作用的Meta分析_米登海.pdfVIP

Review Articles Chin J Evid-based Med 2012, 12(9): 1122-1128 1,2,3 1,2 1 1,2 1,2* 2 1. 7300002. 7300003. 730000 h e Cochrane LibraryPubMedEMbaseCBMCNKIVIP WanFang Data RCT2012 2 1 Google ScholarMedical Martix RCT 2 RevMan 5.1 Meta 17 RCT1 475 Meta OR=3.5195%CI 2.445.07 P0.000 011 2 1 OR=2.9095%CI 1.914.39P0.000 01 2 OR=1.9595%CI 1.213.15 P=0.006 3 OR=2.2895%CI 1.164.49P=0.02 123 Meta Ef ectiveness and Safety of Radiosensitizer Metronidazole Amino Acidum Natrium for Esophagus Carcinoma: A Meta-Analysis 1,2,3 1,2 1 1,2 1,2* 2 MI Deng-hai , REN Wei-wei , TIAN Jin-hui , LI Zheng , YANG Ke-hu , XU Song 1. Evidence-Based Medicine Center, Lanzhou University, Lanzhou 730000, China; 2. h e First Clinical Medicine College, Lanzhou University, Lanzhou 730000, China; 3. Gansu Provincial Second Peoples Hospital, Lanzhou 730000, China Abstract Objective To evaluate the ef ectiveness and safety of radiosensitizer metronidazole amino acidum natri- um (CMNa) for esophagus carcinoma. Methods Databases including h e Cochrane library, PubMed, EMbase, CBM, CNKI, VIP and WanFang Data were searched from their establishment dates to Feb. 1st 2012 for randomized controlled trials (RCTs) of CMMa for esophagus carcinoma. Two reviewers independently screened literature and assessed the qual- ity of the included studies and extracted data. Meta-analysis waw conducted using RevMan 5.1 sot ware. Results A total of 17 RCTs involving 1 475 patients met the inclusion criteria. Results of meta-analyses showed that: a) As for short-term response, the total ef ectiveness of th