草酸脱羧酶的性质及应用研究进展-食品科学.PDFVIP

262 2015, Vol.36, No.01 食品科学 ※专题论述 草酸脱羧酶的性质及应用研究进展 * 贺俊斌，林日辉 ，韦成昱，龙 寒，梁宇薇，陈阳阳，高 华，杜侣佩 （广西民族大学海洋与生物技术学院，化学与生物转化过程新技术广西高校重点实验室，广西南宁 530006 ） 摘  要：草酸脱羧酶（oxalate decarboxylase ，oxdc ）属Cupin蛋白超家族，是一种包含Mn2+ 的均一聚合酶，能够在 没有辅因子的条件下催化草酸转化为甲酸和Co2 ，是植物、微生物中促使草酸代谢降解的主要酶之一。该酶已在农 业、食品、工业生产、医疗和生物监测等领域得到了广泛的应用。本文综述近年来在oxdc来源、结构、作用以及 实际应用方面的研究，着重讨论其在泌尿系统草酸盐结石病症方面的作用，为有效预防治疗泌尿系统结石症的研究 提供理论参考。 关键词：草酸；草酸脱羧酶；Cupin蛋白超家族；泌尿系统 Properties and Applications of Oxalate Decarboxylase * HE Junbin, LIN Rihui , WEI Chengyu, LONG Han, LIANG Yuwei, CHEN Yangyang, GAO Hua, DU Lüpei (Key Laboratory of New Techniques for Chemical and Biological Conversion Process, School of Marine Sciences and Biotechnology, Guangxi University for Nationalities, Nanning 530006, China) Abstract: oxalate decarboxylase (oxdc) is a homogenous polymerase with manganese ion and belongs to the Cupin protein superfamily. in plants and microorganisms, oxdc is one of the main enzymes which can catalyze the decomposition of oxalate into formic acid and Co2 without cofactors. it has been applied widely in agriculture, food, industrial process, medical, biological monitoring and other fields. in this paper, the source, structure, function and practical applications of oxdc are reviewed, with particular discussion on the role and advantages of oxdc in urinary oxalate stones. this will provide important theoretical reference for the effective prevention and treatment of urinary tract stones. Key words: oxalic acid; oxalate decarboxylase; Cupin protein superfamily; urinary system 中图分类号：Q55 文献标志码：a 文章编号：1002-6630 （2015 ）01-0262-06 doi:10.7506/spkx1002-6630-201501050