鼻咽癌放射治疗患者口咽部真菌感染分析.PDFVIP

7·32 · Chin J Nosocomiol Vol. 13 No. 8 2003 ·论 　著· 鼻咽癌放射治疗患者口咽部真菌感染分析 郑秀英 ( 宁波市第二医院 , 浙江 宁波 315010) 摘要 : 目的 　调查分析鼻咽癌患者放疗过程中并发口咽部真菌感染及相关因素 ,探讨行之有效的预防对策 ,指导 临床护理。方法 　对 1999～2001 年鼻咽癌行放射治疗住院患者的出院病历进行统计学分析。结果 　128 例中经 咽拭子培养证实 ,发生口咽部真菌感染 31 例 , 占24. 2 % ;检出致病真菌主要为白色念珠菌和热带念珠菌 ;鼻咽癌 放射治疗并口咽部真菌感染与肿瘤自身免疫功能低下、放疗导致放射性口腔粘膜损伤、机体屏障破坏、不合理应 用抗生素和糖皮质激素等因素有关 ,并且随着住院时间延长 ,真菌感染发生率增加。结论 　应明确预防感染的重 要性、做好消毒隔离工作、改善病房环境、合理应用抗生素和激素。 关键词 : 鼻咽癌 ; 放射治疗 ; 真菌 ; 医院感染 ; 预防 中图分类号: R379 　　文献标识码 : A 　　文章编号 : (2003) Nasopharyngeal Carcinoma Combined with Oropharynx Fungus Infection During Radiotherapy : Analysis and Prevention ZHEN G Xiuying ( The No . 2 Hospital of N in gbo , N in gbo 315010 , China) Abstract : OBJECTIVE To investigate and analyse the nasopharyngeal carcinoma patients combined with oropharynx fungus infection during radiotherap y and its relative factors. METHODS Medical records of nasopharyngeal carcinoma patients from 1999 to 2001 in our hospital were statistically analysed. RESULTS There were 31 nasopharyngeal carcinoma patients combined with oropharynx fungus infection from 128 cases , the infection rate was 24. 2 %. The fungus detected primarily was Candida albicans and C. t ropicalis . Nasopharyngeal carcinoma patients combined with oropharynx fungus infection during radiotherapy were relative to low tumor autoimmunity function , oral mucosal lesion resulted in radiotherap y , destruction to body barrier , improper application of antibiotic and glucocorticoids and so on. CONCL USIONS The significance of prevention , sterilization and isolation , changing the