非那雄胺治疗良性前列腺增生症伴慢性前列腺炎140例疗效观察.docVIP

非那雄胺治疗良性前列腺增生症伴慢性前列腺炎140例疗效观察【中图分类号】R697.3 【文献标识码】A 【文章编号】1672－3783(2012)07－0374－01 【摘要】　目的　观察非那雄胺治疗良性前列腺增生症伴慢性前列腺炎的临床疗效。方法　选择临床确诊的良性前列腺增生伴慢性前列腺炎患者140例，口服非那雄胺(5mg/ d) 3个月，在治疗前和治疗3个月后分别检查国际前列腺症状评分( IPSS)、尿流率、残余尿量、前列腺体积、前列腺液常规。结果　治疗后IPSS 平均降低31.7%，最大尿流率平均升高39.2 %，残余尿量平均减少38.6 % ，前列腺体积平均缩小18.1 % ，前列腺液中白细胞计数平均减少39.8 %。前列腺液检查好转率50.0 %，其中前列腺体积≥40ml 组和 40ml 组的前列腺液检查好转率分别为66.7 %及31.6%，二组间比较差异有统计学意义( P 0. 05) 。结论　非那雄胺可有效治疗伴慢性前列腺炎的良性前列腺增生症,对前列腺体积较大者效果更好。 【关键词】　前列腺炎；非那雄胺；前列腺增生 CLINICAL EFFECTS OF FINASTERIDE ON BENIGN PROSTATIC HYPERPLASIA WITHCHRONIC PROSTATITIS Chen dake Hanweiwen Baowenshuo . Department of Urinary Surgery , The Wenzhou third Hos pital, Wenzhou325000 , China 【Abstract】 　Objective 　To observe the clinical efficacy of finasteride on benign prostatic hyperplasia(BPH) with chronic prostatitis (CP) . Methods 140 patient s with BPH and CP had received oral administ ration of finasteride (5 mg/ d) for 3 months. IPSS , urine flow rate , residual urine volume , prostatic volumeand expressed prostatic secretion ( EPS) were detected before and af ter t reatment . Results After t reatment , maximalurine flow rate increased by 39.2 % , but IPSS , residual urine volume , prostatic volume and leucocyte count in EPS decreased by 31.7 % , 38.6 % , 18.1 % and 39.8 % on average , respectively. Total improvement rate of EPS examinationwas 50.0 % , but the improvement rate in patient s with prostatic volume ≥40ml was superior to that in patient s withprostatic volume 40ml ( 66.7 % vs 31.6 % , P 0. 05 ) . Conclusion Combined use of inasteride is effective for t reating patient s with BPH and CP,especially for those with bigger prostate. 【Key words】 　　prostatitis ; finasteride ; prostatic hyperplasia 良性前列腺增生症(BPH) 和前列腺炎均是男性泌尿生殖道常见良性疾病，目前认为二者可能具有互相诱导的关系［1］ 。非那雄胺治疗良性前列腺增生症(BPH) 具有良好的疗效, 本文将其用于治疗BPH 伴有慢性前列腺炎(CP) 的疗效做。2008 年9月—2010 年3月，我们应用非那雄胺治疗BPH 伴CP 患者40例，取得了较好的治疗效果，现报告如下。 1 　资料与方法 1. 1 　一般资料　 本组140例BPH伴CP患者均为门诊患者, 年龄50～72岁，平均61. 4岁。BPH诊断是根据临床表现、直肠指检、B 超、尿流率测定