临床常见的药物配伍禁忌（Incompatibility of drugs commonly used in clinic）.doc

临床常见的药物配伍禁忌（Incompatibility of drugs commonly used in clinic） Incompatibility of drugs commonly used in clinic When a drug is not effective, it is necessary to select other drugs for proper compatibility. But not all combinations are reasonable, and make some of the drugs reduced, leading to treatment failure; some compatibility to side effects or toxicity enhanced, causing serious adverse reaction; some compatibility of the therapeutic action over enhancement, beyond the ability of the body can withstand, can also cause adverse reactions, and even endanger patients. These combinations are incompatible with each other. Incompatibility of drugs commonly used in clinic 1. beta lactam drugs with probenecid combination, can prolong the former decrease in renal tubular secretion increased, blood drug concentration and action time. Therefore, we should pay attention to reduce the dosage of the former when the two are used together. 2. beta lactam drugs should not be compatible with acidic or alkaline drugs. Such as: aminoglycosides, amino acid, erythromycin, lincomycin, vitamin C, sodium bicarbonate, aminophylline, monosodium glutamate etc.. Therefore, the infusion can only be dissolved in physiological saline drugs, can not be dissolved with Glucose Injection. 3. do not mix with blood, plasma, hydrolyzed protein and fat milk. Other beta lactam drugs should also be noted. 4. cephalosporins (especially the first generation cephalosporins) and can not be efficient diuretics (such as furosemide) combined to prevent the occurrence of serious kidney damage. Penicillin can not be compatible with penicillin. 5. cefoxitin sodium and cephalosporin were most antagonistic effects of combined application of antibacterial efficacy can be weakened. In combination with aztreonam, it plays an antagonistic action both in vivo and in vitro, and does not interfere with efficacy in the field of efficacy, such as penicillin, oxacillin, erythromycin, vancomycin, etc.. 6. aminoglycoside ototoxi