依达拉奉促进机械性周围神经损伤后神经功能恢复有效证明.docVIP

依达拉奉促进机械性周围神经损伤后神经功能恢复的有效证明 依达拉奉可以减轻缺血再灌注诱导的周围神经损伤，但对机械性因素引起的周围神经损伤的治疗效果及机制不甚明了。来自中国大连医科大学附属第二医院南丰博士所领导的团队，以止血钳钝性钳夹大鼠坐骨神经建立周围神经损伤模型，连续2周腹腔注射3mg/kg依达拉奉干预。结果显示依达拉奉干预使周围神经损伤模型大鼠坐骨神经功能指数明显升高，且坐骨神经中丙二醛含量下降，超氧化物歧化酶活性上升，同时L4-6节段脊髓前角细胞中抗凋亡蛋白Bcl-2的表达上升，促凋亡蛋白Bax的表达下降。表明依达拉奉可通过缓解自由基的损伤和抑制脂质过氧化，调节凋亡相关蛋白的表达，促进由于机械性因素损伤神经的再生。相关文献发表于《中国神经再生研究（英文版）》杂志2014年9月第18期。 免疫组化染色显示，连续2周腹腔注射3mg/kg依达拉奉治疗周围神经损伤模型大鼠后，脊髓前角细胞中Bax的表达减少 Article: Edaravone promotes functional recovery after mechanical peripheral nerve injury, by Teng Zhang, Zhengwei Li, Jianli Dong, Feng Nan, Tao Li, Qing Yu (Department of Orthopedics, the Second Affliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China) Zhang T, Li ZW, Dong JL, Nan F, Li T, Yu Q. Edaravone promotes functional recovery after mechanical peripheral nerve injury. Neural Regen Res. 2014;9(18):1709-1715. 欲获更多资讯： HYPERLINK /Neural Regen Res Edaravone promotes functional recovery after mechanical peripheral nerve injury Edaravone has been shown to reduce ischemia/reperfusion-induced peripheral nerve injury. However, the therapeutic effect of edaravone on peripheral nerve injury caused by mechanical factors is unknown. Researchers from the Second Affliated Hospital of Dalian Medical University, China led by Feng Nan established a peripheral nerve injury model by crushing the sciatic nerve using hemostatic forceps, and then administered edaravone 3 mg/kg intraperitoneally. The sciatic functional index and superoxide dismutase activity of the sciatic nerve were increased, and the malondialdehyde level was decreased in animals in the edaravone group compared with those in the model group. Bcl-2 expression was increased, but Bax expression was decreased in anterior horn cells of the L4–6 spinal cord segments. These results indicated that edaravone has a neuroprotective effect following peripheral nerve injury caused by mechanical factors through alleviating free radical damage to cells and inhibiting lipid peroxidation, as well as regul