前列腺间质肉瘤临床病理观察.pdfVIP

· 临床病理· 2008年1月第46卷第1期 前列腺问质肉瘤临床病理观察 刘定荣 李 伟 (重庆市涪陵中心医院病理科，重庆408000) 【摘要】目的 探讨前列腺问质肉瘤的I临床病理特征、病理诊断及鉴别诊断。方法对1例前列腺问质肉瘤作常规HE染色及 免疫组织化学标记，在显微镜下观察组织学形态及免疫组化表达，并进行文献复习。结果 前列腺问质肉瘤主要由排列成束 状、编织状的长梭形细胞构成，短梭形细胞散在于长梭形细胞之间，细胞异型性明显，肿瘤内无腺性成分。肿瘤细胞 Vimentin、CD34呈阳性表达。结论 前列腺间质肉瘤是一种少见的发生于前列腺特异性问质细胞的恶性肿瘤。病理诊断主要 依靠病史及病理组织学形态和免疫组织化学，CD34阳性是诊断该肿瘤的重要依据之一。鉴别诊断主要包括发生于前列腺 的平滑肌肉瘤、恶性神经鞘膜瘤、横纹肌肉瘤等。 [关键词】前列腺问质肉瘤；病理诊断；鉴别诊断；免疫组化 【中图分类号】R737．25 【文献标识码】A 【文章编号】1673—9701(2008)O1—92—02 Clinicopathologic Features of Prostatic Stromal Sarcoma L／U Dingrong 12 Wei Department of Pathology，Cen~M Hospital of Fuhng，Chongqing 408000 【Abstract】0bjective To study the clinical and pathological features and the pathological diagnosis of the prostatic stromal sarcoma (PSS)．Methods One case of PSS Was studied with light microscopy and immunohistochemical staining，as well as review of the literature．Results PSS Was composed of long spindle-shaped cells，these ceHs arranged in interlacing fascicles．Shoa spindle—shaped cells scatter at the long spindle-shaped cells．There were no gland elements in the tumor．Immunohistochemically，vimentin and CD34 were positive．Conclusion S~omal s~coma rarely OCCUI~ in prostate．It originates from specialized prostatic stromal cel1．Its patho~gical diagnosis should be combined with history，histopathological characteristics and immunohistochemistry．Positive of CD34 is one of the most important evidence for pathological diagnosis of PSS．The differential diagnosis of this tumor includes leiomyosareoma， malignant schwannoma，rhabdomyosareoma，and SO on． 【Key Words】Prostatic stromal sarcoma；Pathology diagnosis；D~erenfial diagnosis；Immunohistochemistry 前列腺间质肉瘤(Prostatic stromal sarcoma，PSS)是一种发 10cmX 8cm，左侧叶内见一6cmX 5cmX4cm大小肿块，质硬，包 生于前列腺特异性间质的极少见的恶性肿瘤。1998