乳铁蛋白作为药物载体的研究进展.PDFVIP

药学学报 Acta Pharmaceutica Sinica 2015, 50 (6): 675−681 ·675 · 乳铁蛋白作为药物载体的研究进展 1 1 2* 1* 唐慧娴 , 张振海 , 赵志英 , 吕慧侠 ( 中国药科大学 1. 药学院, 2. 中药学院, 江苏 南京 210009) 摘要: 乳铁蛋白作为一种从乳汁中提取而得的属于先天免疫系统的食品蛋白, 除了具有能够结合和运输铁 离子的主要功能外, 还具有广谱抗菌、抗病毒、抗寄生虫、抗辐射、抑制肿瘤细胞生长及调节机体免疫反应等 广泛的生物学活性。目前常作为食品、化妆品的添加剂。随着研究的深入, 乳铁蛋白在药用领域作为药物载体 的研究越来越受到广泛关注。根据乳铁蛋白作为药物载体的不同特点, 本文分类概述其在脑靶向、肝肿瘤靶向、 肺肿瘤靶向和口服给药系统中的研究进展。 关键词: 乳铁蛋白; 药物载体; 靶向; 口服给药 中图分类号: R943 文献标识码: A 文章编号: 0513-4870 (2015) 06-0675-07 Research progress of lactoferrin as drug carriers 1 1 2* 1* TANG Hui-xian , ZHANG Zhen-hai , ZHAO Zhi-ying , LÜ Hui-xia (1. Department of Pharmaceutics, 2. Department of Chinese Medicine, China Pharmaceutical University, Nanjing 210009, China) Abstract : Lactoferrin (Lf) is one of the food protein belonged to the innate immune system. Apart from its main biological function of binding and transport of iron ions, lactoferrin also has many other functions and properties such as antibacterial, antiviral, antiparasitic, catalytic, anti-cancer, anti-allergic and radioprotecting. Lf is usually used as additives of food and cosmetics. The research of lactoferrin has been increasingly reported, and the application of lactoferrin as a drug carrier has drawn extensive attention over the recent year. In this paper, researches of lactoferrin as drug carriers are classified and summarized in brain targeting, liver tu