空气污染与神经退行性疾病.PDFVIP

第23卷第8期 生命科学 Vol. 23, No. 8 2011年8月 Chinese Bulletin of Life Sciences Aug., 2011 文章编号：1004-0374(2011)08-0784-06 空气污染与神经退行性疾病 吴远双，孟庆雄，魏大巧，白　洁* ( 昆明理工大学生命科学与技术学院，昆明650224) 摘　要：随着现代社会工业的发展，空气污染日益严重，空气污染对人体的损害也越来越大。空气污染中 的有害物质，能通过各种途径引起各系统的疾病，甚至会影响儿童的身体和智力发育。研究发现，长期暴 露或急性暴露在某些空气污染物中可以直接损伤中枢神经系统，或污染物引起呼吸系统和免疫系统等产生 有害因子，通过外周循环到达大脑，导致大脑的神经炎症、神经毒性、氧化应激等反应，最终产生神经退 行性病变，如阿尔茨海默病(Alzheimer’s disease, AD)、帕金森病(Parkinson’s disease, PD) 等。 关键词：空气污染；神经炎症 ；神经毒性；氧化应激 ；神经退行性疾病 Q494 X503,1 R742.5 中图分类号： ； ； 文献标志码 ：A Air pollution and neurodegenerative diseases WU Yuan-Shuang, MENG Qing-Xiong, WEI Da-Qiao, BAI Jie* (College of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, China) Abstract: With the quick development of modern industry, air pollution has been exploding in the past decades, which consequently results in more and more damage to human body. Environmental toxins from polluted air can cause pathologic change of every system in our body and even influence body and intelligence development of children. Recently, it has been reported that chronic exposure or acute exposure to the pollution matters could cause direct damage on the central nervous system (CNS), or stimulate some susceptible system (e.g., the respiratory system, immune system, etc.) to produce some harmful factors, which can reach the brain though peripheral circulation and then cause neuroinflammation, neurotoxicity, oxidative stress, eventually result in neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. This review focuses on the pathways and the mechanisms of neurodegenerative di