卡维地洛,倍他乐克治疗小儿扩张型心肌病疗效及安全性比较.docVIP

卡维地洛治疗小儿扩张型心肌病疗效及安全性1，1*，2，1，白永虹1 （1:重庆医科大学附属儿童医院心内科；儿童发育疾病研究省部共建教育部重点实验室，重庆400014；2:德阳市人民医院，四川 618000） (摘要( 目的：对卡维地洛、倍他乐克治疗小儿扩张型心肌病的疗效、耐受性及安全性进行比较。方法：收集2006年9月2011年月住院的患儿卡维地洛组患儿治疗后与治疗前比较，、、减少有统计学有统计学卡维地洛组与倍他克组患儿比较，心脏收缩功能无；两组患儿达到药物最大耐受剂量的百分比，卡维地洛组高于倍他克组，统计学差异。两组患儿均明显不良反应。卡维地洛能改善DCM患儿心室收缩功能，心室，具有较好耐受性及安全性在耐受性方面，卡维地洛可能较倍他克好。中图分类号 R725.4 Comparison effect and safety of carvedilol with metoprolol in children with dilat ed cardiomyopathy Chi Xiaoqing1,Zhong Jiarong1*,Xie Shenghui2,Ji xiaojuan1,Bai Yonghong1 (1:Department of Cardiology, Children’s Hospital, Chongqing Medical University , Key Laboratory of Developmental Diseases in Childhood (Chongqing Medical University), Ministry of Education Chongqing ,400014,China2:Peoples Hospital of De Yang city in Sichuan Proviance, 610000, China) (abstract( Objective To compare the efficacy,safety,tolerance of carvedilol with metoprolol for dilated cardiomyopathy in children. Methods Children dilated cardiomyopathy from September 2006 to November 2011 in Children’s Hospital of Chongqing Medical University randomly divided into carvedilol group(24 cases) and metoprolol group(24 cases) .Size of heart and cardiac function,safety and tolerance in patients after treatment of carvedilol or metoprolol were observed and compared with each other.Results Cardiothoracic Ratio,LVEDV, LVESV,LVmass significantly decreased after treatment in comparison with befor treatment in carvedilol group and metoprolol group (P0.05).LVEF,LVFS significantly increased after treatment than before in two groups (P0.05).Carvedilol group and metoprolol group was no significant differences in heart size and function(P0.05). The percentage of the maximum tolerated dose of drug was slightly higher carvedilol group in comparison with metoprolol group(P0.05). They were no apparent adverse reactions. Conclusions Carvedilol , metoprolol can improve ventricular systolic function , reverse left ventricular remodeling,and have good tolerability and safety in children wi