妊娠高血压综合征血小板参数的监测及临床意义..doc

妊娠高血压综合征血小板参数的监测及临床意义 赵哲人 浙江省嘉兴市妇幼保健医院 314000 [摘要]目的：探讨妊娠高血压综合征患者血小板参数的变化及临床意义。方法：将我院2007年3月至2009年3月收治的352例孕妇进行回顾性分析，根据诊断标准分为PIH组和正常孕妇组。监测平均血小板体积（MPV）、血小板分布宽度(PDW)、血小板计数（PLT）及血小板压积(PCT)，并比较各组间的差异。结果：PIH组MPV、PDW明显高于正常孕妇组，PLT及PCT明显低于正常孕妇组，差异具有统计学意义（P0.05），轻度、中度及重度PIH患者MPV 、PDW值呈进行性增高，PLT、PCT呈进行性降低，差异均有统计学意义（P 0.05）。结论：血小板参数对预测妊高征的发生有一定临床价值，而且与疾病的进展与严重程度具有相关性，为妊高征的诊断、治疗、疗效及预后判定提供了理论依据。 [关键词]妊娠高血压综合征；血小板参数； Clinical Significance on Platelet Parameters in Patients with Pregnancy induced Hypertension Syndrome [Abstract]Objective: To explore the platelet parameters changes and its clinical significance of patients with pregnancy induced hypertension syndrome. Method: A total of 352 patients with a diagnosis of pregnancy induced hypertension syndrome from March 2007to March 2009 in our hospital were included in the study retrospectively. Patients were divided into the pregnancy induced hypertension syndrome group(PIH group) and the late pregnancy women group(NP group). Platelet parameters of Platelet count(PLT),mean platelet volume (MPV),platelet volume distr/but～onwidth(PDW),platelet cdt (PCT) were compared. Results: MPV and PDW of PIH group was higher than that of NP group (P0.05), PLT and PCT in the PIH group were lower than the NP group(P0.05). MPV and PDW in severe PIH, moderate PIH and mild PIH were progressively increased (P0.05). PLT and PCT in severe PIH, moderate PIH and mild PIH were progressively degraded (P0.05). Conclusion: The detection of platelet parameters is helpful for predicting PIH，and have association with progress and severity of PIH. Platelet parameters may be helpful for PIH patients in diagnosis, treatment, and so on. [Key words] Pregnancy induced Hypertension Syndrome；Platelet Parameters 妊娠高血压综合征是指妊娠期发生或出现以血压高于正常范围为主要特征并伴随其他生理病理改变的高危妊娠，是对母婴具有极大危害的并发症。为探讨血小板参数与妊高征关系，笔者选择2007年3月至2009年3月在我院进行定期产检并分娩，资料记录完整的孕产妇352例进行回顾性分析，现报道如下。 一般资料与方法 1.1 临床资料 选择2007年3月至2009年3月在我院定期进行产检并分娩，资料记录完整的孕产妇352例，以上孕妇均无妊娠合并症及慢性病史。孕期检查无异常、分娩结局为正常分娩者为正常孕妇组，113例，年龄24～35岁，