英文PPT报告.pptVIP

Development and characterisation of chitosan films impregnated with insulin loaded PEG-b-PLA nanoparticles(NPs):A potential approach for buccal delivery of macromolecules粘附壳聚糖薄膜的载胰岛素PEG-b-PLA纳米粒的 研究—大分子药物口服传递给药方法;Introduction of journal;;;Materials;Experiment ; PEG-b-PLA (5%and10% polymer concentrations ) dichloromethane(o) sonication for 20 s primary emulsion (w1/o) 1% PVA solution sonicate for 20s (w1/o/w2) dilute in 100 mL of 0.3% PVA magnetic stirring for 3 h solvent evaporation ultra-centrifugation 30min lyophilise for 24 h store at 4 ?C until further use ;;Formulation ;Results:The SEM micrograph of blank NPs;The cause analysis of blank-NPs-10; 3.Freeze-drying of PEG-b-PLA NPs: effect of cryoprotectants;1.A typical freeze-drying cycle NPs size and P.I no significant effect . 2.Size and P.I. at different NP concentrations before and after the addition of TH remained unchanged. 3. PVP lead to slightly smaller diameters when 2 mg/ml of NPs and the formation of large aggregates with very high P.I. (≈1). 4.The TH proved to be an effective cryoprotectant. ;Determination of encapsulation efficiency;Insulin loaded PEG-b-PLA NPs ;Result: insulin loaded PEG-b-PLA NPs;Result:Composition and characteristics of NPs-Insulin;In vitro insulin release studies;Results:Release profiles of insulin ;1;3.1 Film preparation and insulin loaded PEG-b-PLA NPs incorporation; Determination of morphological and mechanical properties of Ch-films;middle regions of formulated films ; ;Conclusion and prospect;Thank You!