干燥综合征中西医结合探究新进展.docVIP

干燥综合征中西医结合探究新进展摘 要:干燥综合征干燥综合征(SS)属于一种慢性自身免疫性疾病,常累及外分泌腺(包括唾液腺、泪腺、汗腺)在静息和刺激状态下唾液流率均降低,进而导致语言困难、进食障碍、口腔念珠菌病和慢性涎腺炎等一系列改变。根据其临床表现在古典医籍中属“燥症”范畴。近年来,中医学对其辨证分型论治取得较好的效果。基础研究方面,人们医学运用免疫组化、免疫印迹法等针对SS患者唾液腺破坏机制开展了大量基础性研究,目前已深入至水分子通道蛋白(aquaporin, AQP)的基因层面。本文就SS的中西医结合新进展进行综述。 关键词:干燥综合征;活血化瘀;唾液腺;中西医结合 ? 中图分类号:R758.61 文献标识码:A 文章编号:1673-7717(2010)04-0778-04 Sjogren’s Syndrome in the New Progress of Integrative Medicine LIN Qing,ZHANG Qian?de, WEI Mu?xin (The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangshu,China) Abstract:Sjogren’s syndrome (SS) is a form of chronic autoimmune diseases,often involving the exocrine gland (including the salivary glands, lacrimal gland, sweat glands) in the resting and stimulated salivary flow rates of a state of reduced,which led to language difficulties, eating disorders, oral candidiasis and chronic salivary gland Yandeng a series of changes.According to their clinical performance of medical membership in the classical case of “dry disease” category.In recent years, Chinese medicine for its syndrome type to achieve better results on the rule. In Basic research,People using immunohistochemistry, Western blot and other failure mechanism for the SS salivary glands in patients with a large number of basic research carried out, currently it has in-depth to the water molecule channel protein (aquaporin, AQP) the genetic level. In this paper, about SS of Chinese and Western Medicine are reviewed in light of new advances.? Key words:sjogren’s syndrome; blood-activating and stasis-resolving; salivary; combining Chinese and Western medicine 收稿日期:2009-11-19 基金项目:江苏省兴卫工程中医药领军人才基金项目(苏卫规财2007-158);江苏省科技厅国际合作计划资助项目(BR2006058) 作者简介:林青(1982-),女,江苏南京人,硕士研究生,研究方向:中西医结合基础与临床。 通讯作者:魏睦新(1959-),男,江苏南通人,教授,博士研究生导师,医学博士,研究方向:中医证的客观化研究及胃肠动力中药先导化合物研究。E?mail: weimuxin@njmu.省略。 1 脏腑核心辨证与基础治疗? 近年来,人们将中医的脏腑辨证用于指导干燥综合征SS治疗,认为本病在不同的阶段,损及不同的脏腑,应该选用不同的基础治疗处方。? 冯建华[1]将本病分为:肺胃阴伤型、肝肾阴虚型、脾肾阴虚型、脾胃阳虚型、气滞血瘀型。刘征堂等[2]认为