氯吡格雷及阿司匹林联合治疗非ST段抬高型心肌梗死临床观察.docVIP

氯吡格雷及阿司匹林联合治疗非ST段抬高型心肌梗死临床观察[摘要] 目的 观察氯吡格雷与阿司匹林联合治疗非ST段抬高型心肌梗死的临床疗效。 方法 选择本科非ST段抬高型心肌梗死患者96例，随机分为治疗组50例与对照组46例，在常规治疗的基础上，治疗组给予氯吡格雷每日75 mg（首剂300 mg），阿司匹林每日100 mg，对照组仅给予阿司匹林100 mg，观察4周，观察两组患者的临床疗效与不良反应。 结果 治疗4周后，治疗组总有效率为88%，对照组为63%，两组比较差异有统计学意义（P 0.05）。 结论 氯吡格雷与阿司匹林联合治疗非ST段抬高型急性心肌梗死可有效降低心血管事件、缺血性脑卒中，临床疗效好，值得借鉴。 [关键词] 氯吡格雷；阿司匹林；非ST段抬高型心肌梗死；临床观察 [中图分类号] R972 [文献标识码] A [文章编号] 1674-4721（2012）06（a）-0065-02 Clinical observation of clopidogrel and aspirin in the treatment of non ST segment elevation myocardial infarction LI Mingyu The People’’s Hospital of Tumen City in Jilin Province, Tumen 133100, China [Abstract] Objective To observe the clinical curative effect of clopidogrel combined with aspirin in the treatment of non ST segment elevation myocardial infarction. Methods Ninty six patients were randomly divided into the treatment group 50 cases and control group of 46 cases, based on the routine treatment, the treatment group were treated with clopidogrel 75 mg daily (the first dose of 300 mg), aspirin 100 mg daily, the control group was only given aspirin 100 mg, observed for 4 weeks, the clinical efficacy and adverse reaction of two groups patients were observed. Results After 4 weeks treatment, the total effective rate of the treatment group was 85.7%, the control group was 63.3%, the two groups had significant difference (P 0.05). Conclusion The clopidogrel and aspirin in the treatment of non ST segment elevation acute myocardial infarction is effective in reducing cardiovascular events, has good curative effect, less adverse reaction, it is worthy of popularization and application. [Key words] Clopidogrel; Aspirin; Non ST segment elevation myocardial infarction; Clinical observation 冠状动脉粥样硬化性心脏病指由于冠状动脉粥样硬化管腔狭窄、痉挛或阻塞导致心肌缺血、缺氧或坏死而引起的心脏病，它是动脉粥样硬化导致器官病变的最常见类型[1]。急性心肌梗死由于冠状动脉急性狭窄或闭塞，供血持续减少或终止，所产生的心肌严重缺血和坏死。分为ST段抬高型心肌梗死和非ST段抬高型心肌梗死，治疗上在严格掌握适应证的情况下及早进行溶栓、介入治疗与外科手术治疗基础上，积极抗凝、抗血小板治疗尤为重要，并能明显降低患者心血管事件、脑梗死、再发心肌梗死，提高远期疗效、生活质量。本文旨在观察氯吡格雷与阿司匹林联合治疗非ST段抬高型急性心肌梗死的