实验性肝纤维化过程中Activin A表达变化与银杏叶提取物的逆转效应.pdfVIP

中国组织工程研究 临床康复 第 12孝 第2 2008—0l一08出版 Journal ofClinical Rehabilitative Tissue Engineering Research January 8，2008 Vo1．12，No 2 基础医学 实验性肝纤维化过程~Activin A表达变化与银杏叶提取物的逆转效应★ 刘 沽，时昭红，胡 伟，吴玉芳，刘 嵩 Effect of Ginkgo Biloba extract on the expression of Activin A during the process of hepatic fibrosis Liu Hao，Shi Zhao·hong，Hu Wei，Wu Yu·fang，Liu Song Abstract AIM：Activin A，a member of Wansforming growth factor superfamily，is the negative regulator factor in liver regenemtion Department o1 ． In this study．the effects ofextract ofGinkgo Biloba on hepatic fibrosis and the expression ofActivin A in rats with cirrhosis were investigated． Digestion， Wuhan First Hospital， METHoDS：The experiment was performed at in the Central Laboratory of Wuhan First Hospital from September 2005 to December Wuhan 430022． 2006 Thirty—six male SD rats of(1 60±20)g were randomized into 3 groups：control group，model group and treatment group．② Hubel Province． China Except the rats in the control group．others were intraperitoneally injected with 500 mL／L CCh for 8 weeks to establish models of hepatic fibrosis．Meanwhile，the extract treatment group was infused with the extract of Ginkgo Biloba(Chinese drugs preparation Liu Hao★．Master, laboratory of Wuhan First Hospital，detected by Hubeu Wushi Medicine Industry Co，Ltd．No 02—39 1)daily for 8 weeks⑧After Physician． administration，all anesthetized rats were sacririced．Blood samples were collected for the determ ination of liver function biochemical Department o1