血清超敏C反应蛋白水平与急性脑梗死的相关性分析.pdfVIP

老年医学与保健2008年第14卷第1期 Geriatr Heahh Cate，2008，Vo1．I4．N0．I 血清超敏C反应蛋白水平与急性脑梗死的相关性分析 徐 翔 【摘要】目的 探讨_血清超敏C反应蛋白(hs—CRP)水平与急性脑梗死的相关性。方法 100例72 zJ,It,~内的急 性腑梗死病人分为A组(分脑血栓形成、脑栓塞、腔隙性脑梗死三个亚组)，8O例健康对照组为B组，分别测入院当天、 1月后的hs—CRP水平，进行神经功能缺损评分(NlHSS)并两者比较，测A组病人人院当天的血糖、血脂、血压、D一 二聚体水平，计算梗塞面积，并与hs—CRP水平进行相关性分析。结果 (1)急性期脑梗死组的hs—CRP水平高于对照 组(PO．0001)；急性期三亚组之间差异也有统计学意义(PO、0001)，其中脑栓塞组hs—CRP水平最高，1月后仅栓寒 组与腔梗组hs—CRP水平之间的差异具有统计学意义(，】=O．028)；(2)脑梗死急性期hs—CRP水平与急性期NIHSS评分、 梗塞面积、 糖、甘油三脂、低密度脂蛋白、D一二聚体、收缩压水平呈正相关，与高密度脂蛋白水平、1月后NIHSS评 分下降百分比呈负相关(PO．0001)。其中NIHSS评分、D一二聚体、ff『l糖三项可进入回归方程 结论 麻清hs—CRP水 平与急性脑梗死的发生、发展相关，与m糖、甘油j脂、高密度脂蛋白、低密度脂蛋白、收缩压等血管性危险因子及 D一二聚体密切相关。 【关键词】急性病； 脑梗塞； C反应蛋白质 【中图分类号] R743．330 【文献标识码] A 【文章编号]1008—8296(2008)一O1—0039—03 Correlation between serum high-sensitive C-reactive protein level and acute ischemic stroke XU Xiang DtTartment ofNeuwlogy ofHrmdong Hospital,Fudan Universi0，，Shanghai 200040，China 【Abstract】objective To study the correlation hetween serum high-sensitive C-reactive protein level and acute ischenfic stroke．Methods Serum high-sensitive C-reactive protein l rel was determined in 100 patients(group A)who had onset of ischemic stroke symptoms within 72 h(including three subgroups：48 cases of cerebral thronlb0genes 24 cases of cerebral embolism and 28 cases of lacunax’infarction)，and in 80 heahhy volunteers as nonnal control(group B1．hs— CRP differences in the two groups and the three ischemic stroke subgroups were analyzed．Neurological functional ou[comes ~4ere evaluated both in the acule phase and al the 1一nmnth(bllo~一up i“group A by NIHSS．an(1 the diffe；eoce in NIHSS was analyzed within the three subgroups．The orrelation hetween hs—CRP and risk factms for cerehrovaseulm disease was also anak zed．Results (1 1 Patients with acute ischemic stroke had a significantly higher level of hs—