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Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2010, Article ID 547179, 10 pages doi:10.1155/2010/547179 Research Article Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages P. Allavena,1 M. Chieppa,2, 3 G. Bianchi,4 G. Solinas,1, 5 M. Fabbri,6 G. Laskarin,7 and A. Mantovani1, 8 1 Deptartment Immunology Inflammation, IRCCS Clinical Institute Humanitas, Rozzano, 20089 Milan, Italy 2 Department of Translational Medicine, National Institute of Gastroenterology IRCCS “Saverio de Bellis”, Castellana Grotte, 70013 Bari, Italy 3 Advanced Research Centre for Health (ARCHES), Enviroment and Space, Castellana Grotte, 70013 Bari, Italy 4 Environmental Health Sciences Department, Mario Negri Institute, 20157 Milano, Italy 5 Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA 6 European Commission, Joint Research Centre Institute for Health and Consumer Protection Molecular Biology and Genomics, 21020 (VA) Ispra, Italy 7 Department of Physiology and Immunology, University of Rijeka, 51000 Rijeka, Croatia 8 Department of Translational Medicine, University of Milan, 20121 Milan, Italy Correspondence should be addressed to P. Allavena, paola.allavena@humanitasresearch.it Received 2 August 2010; Revised 18 October 2010; Accepted 21 December 2010 Academic Editor: Nima Rezaei Copyright © 2010 P. Allavena et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Tumor-Associated Macrophages (TAMs) are abundantly present in the stroma of solid tumors and m