distinct effects of calorie restriction and resveratrol on diet-induced obesity and fatty liver formation不同的卡路里限制的影响和白藜芦醇对食源性肥胖和脂肪肝的形成.pdfVIP

Hindawi Publishing Corporation Journal of Nutrition and Metabolism Volume 2011, Article ID 525094, 10 pages doi:10.1155/2011/525094 Research Article Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation Eveliina Tauriainen,1 Mira Luostarinen,2 Essi Martonen,1 Piet Finckenberg,1 Miia Kovalainen,3 Anne Huotari,3 Karl-Heinz Herzig,4, 5, 6 Anne Lecklin,2 and Eero Mervaala1 1 Institute of Biomedicine, Pharmacology, University of Helsinki, Biomedicum Helsinki, P.O. Box 63, 00014 Helsinki, Finland 2 School of Pharmacy, Pharmacology and Toxicology, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland 3 School of Pharmacy, Pharmaceutical Technology, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland 4 Institute of Biomedicine, Physiology, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland 5 Biocenter Oulu, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland 6 Department of Psychiatry, Kuopio University Hospital, P.O. Box 1777, 70211 Kuopio, Finland Correspondence should be addressed to Eero Mervaala, eero.mervaala@helsinki.fi Received 12 January 2011; Accepted 26 July 2011 Academic Editor: Maria Luz Fernandez Copyright © 2011 Eveliina Tauriainen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The potential of resveratrol to mimic beneficial effects of calorie restriction (CR) was investigated. We compared the effects of both CR (70% of ad libitum energy intake) or resveratrol (2 g/kg or 4 g/kg food) on high-fat diet-induced obesity and fatty liver formation in C57Bl