原创力文档association of xmn i polymorphism and hemoglobin e haplotypes on postnatal gamma globin gene expression in homozygous hemoglobin e厦门我协会的多态性和血红蛋白e单在产后γ球蛋白基因表达纯合血红蛋白e.pdfVIP
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association of xmn i polymorphism and hemoglobin e haplotypes on postnatal gamma globin gene expression in homozygous hemoglobin e厦门我协会的多态性和血红蛋白e单在产后γ球蛋白基因表达纯合血红蛋白e
Hindawi Publishing Corporation
Advances in Hematology
Volume 2012, Article ID 528075, 5 pages
doi:10.1155/2012/528075
Research Article
Association of Xmn I Polymorphism and Hemoglobin E
Haplotypes on Postnatal Gamma Globin Gene Expression in
Homozygous Hemoglobin E
Supachai Ekwattanakit,1 Yuwarat Monteerarat,1 Suchada Riolueang,1, 2
Kalaya Tachavanich,3 and Vip Viprakasit2, 3
1 Graduate Program and Medical Scholar Program in Immunology, Department of Immunology, Faculty of Medicine Siriraj Hospital,
Mahidol University, 2 Prannok Road, Bangkok Noi, Bangkok 10700, Thailand
2 Thalassemia Center, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok Noi,
Bangkok 10700, Thailand
3 Hematology/Oncology Division, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road,
Bangkok Noi, Bangkok 10700, Thailand
Correspondence should be addressed to Vip Viprakasit, sivvp@mahidol.ac.th
Received 30 April 2012; Accepted 14 August 2012
Academic Editor: Samir K. Ballas
Copyright © 2012 Supachai Ekwattanakit et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Background and Objectives. To explore the role of cis-regulatory sequences within the β globin gene cluster at chromosome 11 on
human γ globin gene expression related to Hb E allele, we analyze baseline hematological data and Hb F values together with β
globin haplotypes in homozygous Hb E. Patients and Methods. 80 individuals with molecularly confirmed homozygous Hb E were
analyzed for the β globin haplotypes and Xmn I polymorphism using PCR-RFLPs. 74 individuals with com
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