binding of naturally occurring hydroxycinnamic acids to bovine serum albumin结合天然hydroxycinnamic酸牛血清白蛋白.pdfVIP
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binding of naturally occurring hydroxycinnamic acids to bovine serum albumin结合天然hydroxycinnamic酸牛血清白蛋白
Vol.2, No.6, 563-570 (2010) Natural Science
/10.4236/ns.2010.26071
Binding of naturally occurring hydroxycinnamic acids to
bovine serum albumin
1,2 1* 1 1,2
Lucie Trnková , Iva Boušová , Vladimír Kubíček , Jaroslav Dršata
1Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic; *Corresponding Author: Iva.Bousova@faf.cuni.cz
2University of Hradec Králové, Faculty of Education, Hradec Králové, Czech Republic
Received 22 February 2010; revised 12 April 2010; accepted 13 May 2010.
ABSTRACT play crucial role in promoting research on proteins be-
cause they can provide useful information for study of
Hydroxycinnamic acids (HCAs) possess numer-
pharmacological and biological effects of drugs as well
ous biological effects including antioxidant, an-
as conformational changes of proteins caused by drugs.
tiallergic, antimicrobial, and immunomodulatory
Serum albumin is one of the most abundant proteins
activities and due to these properties are widely
in circulatory system of a wide variety of organisms and
used in folk medicine. Nevertheless, they can
one of the most extensively studied proteins at all [4,5].
interact with protein molecules and cause some
structural and functional changes. The possib-
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