原创力文档bioactive fatty acids reduce development of gastric cancer following duodenogastric reflux in rats生物活性脂肪酸减少胃癌在老鼠duodenogastric回流后的发展.pdfVIP
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bioactive fatty acids reduce development of gastric cancer following duodenogastric reflux in rats生物活性脂肪酸减少胃癌在老鼠duodenogastric回流后的发展
Surgical Science, 2012, 3, 34-42
/10.4236/ss.2012.31006 Published Online January 2012 (http://www.SciRP.org/journal/ss)
Bioactive Fatty Acids Reduce Development of Gastric
Cancer Following Duodenogastric Reflux in Rats
1,2 3 4 3
Bjørn Jostein Christensen , Kjetil Berge , Hege Wergedahl , Pavol Bohov ,
Rolf Kristian Berge3,5, Einar Svendsen6,7, Asgaut Viste1,2
1Department of Surgical Sciences, University of Bergen, Bergen, Norway
2Department of Gastrointestinal and Acute Surgery, Haukeland University Hospital, Bergen, Norway
3Institute of Medicine, University of Bergen, Bergen, Norway
4Faculty of Education, Section for Food and Health, Bergen University College, Bergen, Norway
5Department of Heart Disease, Haukeland University Hospital, Bergen, Norway
6The Gade Institute, Section of Pathology, University of Bergen, Bergen, Norway
7Department of Pathology, Haukeland University Hospital, Bergen, Norway
Email: bjch@helse-bergen.no
Received November 2, 2011; revised November 29, 2011; accepted December 16, 2011
ABSTRACT
Background: Bioactive fatty acids such as the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and the
modified fatty acid analogue, tetradecylthioacetic acid (TTA), are known to influence inflammatory processes in the
body. Our aim was to investigate if diets containing fish oil (FO) enriched with bioactive fatty acids could affect in-
flammation and development of glandular stomach carcinogenesis in a duodenogastric reflux (DGR) animal model. We
also wanted to e
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