biochemical parameters alterations in multiple sclerosis a longitudinal study and review of the literature生化参数改变多发性硬化症纵向研究和文献之回顾.pdfVIP

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biochemical parameters alterations in multiple sclerosis a longitudinal study and review of the literature生化参数改变多发性硬化症纵向研究和文献之回顾.pdf

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biochemical parameters alterations in multiple sclerosis a longitudinal study and review of the literature生化参数改变多发性硬化症纵向研究和文献之回顾

Pharmacology Pharmacy, 2012, 3, 248-253 /10.4236/pp.2012.32033 Published Online April 2012 (http://www.SciRP.org/journal/pp) Biochemical Parameters Alterations in Multiple Sclerosis: A Longitudinal Study and Review of the Literature 1* 2 2 2 Nicola Salvatore Orefice , Olga Ferraro , Francesco Barbato , Antonio Carotenuto , Roberta Lanzillo2 2 2 2 , Vincenzo Brescia Morra , Giovanni Coppola , Giuseppe Orefice 1Department of Experimental Pharmacology, Federico II University of Naples, Italy; 2Department Neurological Sciences, Federico II University of Naples, Italy. * Email: nicolasalvatore.orefice@unina.it Received January 10th, 2012; revised February 15th, 2012; accepted March 8th, 2012 ABSTRACT Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) and is characterized by inflammation, demyelination and desctruction of oligodendrocytes and axons. The immunology of MS is complex, in- volving autoreactive Th1 and Th17 lymphocytes, cells of the innate immune system including dedritic, natural killer (NK) and microglia cells, as well as vascular endothelial cells. Multiple Sclerosis (MS) is based by a series of bio- chemical changes affecting to different extent neuronal functions; great attention has been focused on: liver enzymes, thyroid function tests, autoantibodies, lipid profile and uric acid levels. Following the introduction of therapy with drugs that modify the course of disease, more attention has been paid to the change of biochemical parameters, in particular to evaluate possible adverse effects. Aim of this study was to perform a review of the literature on biochemical alterations in treated and untreated M