biochemical frequency control by synchronisation of coupled repressilators an in silico study of modules for circadian clock systems生化频率控制的同步耦合repressilators的在网上研究生物钟系统的模块.pdfVIP

Hindawi Publishing Corporation Computational Intelligence and Neuroscience Volume 2011, Article ID 262189, 9 pages doi:10.1155/2011/262189 Research Article Biochemical Frequency Control by Synchronisation of Coupled Repressilators: An In Silico Study of Modules for Circadian Clock Systems Thomas Hinze, Mathias Schumann, Christian Bodenstein, Ines Heiland, and Stefan Schuster Department of Bioinformatics, Faculty of Biology and Pharmacy, Friedrich Schiller University Jena, E.-Abbe-Platz 1-4, 07743 Jena, Germany Correspondence should be addressed to Thomas Hinze, thomas.hinze@uni-jena.de Received 18 March 2011; Revised 6 July 2011; Accepted 6 July 2011 Academic Editor: Fabio Babiloni Copyright © 2011 Thomas Hinze et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Exploration of chronobiological systems emerges as a growing research field within bioinformatics focusing on various applications in medicine, agriculture, and material sciences. From a systems biological perspective, the question arises whether biological control systems for regulation of oscillatory signals and their technical counterparts utilise similar mechanisms. If so, modelling approaches and parameterisation adopted from building blocks can help to identify general components for frequency control in circadian clocks along with gaining insight into mechanisms of clock synchronisation to external stimuli like the daily rhythm of sunlight and darkness. Phase-locked loops could be an interesting candidate in this context. Both, biology and engineering, can benefit from a unified view resulting from systems modularisation. In a first experimental study, w