原创力文档biocompatibility of porous spherical calcium carbonate microparticles on hela cells生物相容性的多孔球形碳酸钙微粒在海拉细胞.pdfVIP
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biocompatibility of porous spherical calcium carbonate microparticles on hela cells生物相容性的多孔球形碳酸钙微粒在海拉细胞
World Journal of Nano Science and Engineering, 2012, 2, 25-31 25
/10.4236/wjnse.2012.21005 Published Online March 2012 (http ://www.SciRP.org/journal/wjnse)
Biocompatibility of Porous Spherical Calcium Carbonate
Microparticles on Hela Cells
1 2 3 1 1 4 1* 1*
Yaran Zhang , Ping Ma , Yao Wang , Juan Du , Qi Zhou , Zhihong Zhu , Xu Yang , Junlin Yuan
1Laboratory of Environmental Sciences, College of Life Sciences, Central China Normal University, Wuhan, China
2Basic Medical College, Xianning University, Xianning, China
3School of Life Sciences, Fudan University, Shanghai, China
4Nanotechnology Institute, College of Physical Science and Technology, Central China Normal University, Wuhan, China
* *
Email: yangxu@, yuanjl@
Received November 30, 2011; revised December 12, 2011; accepted January 2, 2012
ABSTRACT
Recently there has been a wide concern on inorganic nanoparticles as drug delivery carriers. CaCO3 particles have
shown promising potential for the development of carriers for drugs, but little research had been performed regarding
their safe dosage for maximizing the therapeutic activity without harming biosystems. In this study, we assessed the
biological safety of porous spherical CaCO3 microparticles on Hela cells. The reactive oxygen species (ROS), glu-
tathione (GSH), carbonyl content in proteins (CCP), DNA-protein crosslinks (DPC) and cell via
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