biochemical factors modulating cellular neurotoxicity of methylmercury生化因素调节细胞的甲基汞神经毒性.pdfVIP

Hindawi Publishing Corporation Journal of Toxicology Volume 2011, Article ID 721987, 9 pages doi:10.1155/2011/721987 Review Article Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury Parvinder Kaur,1 Michael Aschner,2 and Tore Syversen3 1 Department of Neuroscience, Norwegian University of Science and Technology, 7489 Trondheim, Norway 2 Departments of Pediatrics and Pharmacology and The Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, B-3307 Medical Center North, 1162 21st Avenue, Nashville, TN 37232-2495, USA 3 Department of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Olav Kyrres Gate 3, 7489 Trondheim, Norway Correspondence should be addressed to Tore Syversen, tore.syversen@ntnu.no Received 30 April 2011; Revised 28 June 2011; Accepted 13 July 2011 Academic Editor: Shelley Bhattacharya Copyright © 2011 Parvinder Kaur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Methylmercury (MeHg), an environmental toxicant primarily found in fish and seafood, poses a dilemma to both consumers and regulatory authorities, given the nutritional benefits of fish consumption versus the possible adverse neurological damage. Several studies have shown that MeHg toxicity is influenced by a number of biochemical factors, such as glutathione (GSH), fatty acids, vitamins, and essential elements, but the cellular mechanisms underlying these complex interactions have not yet been fully elucidated. The objective of this paper is to outline the cellular response to dietary nutrients, as well as to descri