bioinformatics analysis and characteristics of envelop glycoprotein e epitopes of dengue virus生物信息学分析和包络的登革病毒糖蛋白e抗原表位的特征.pdfVIP

J. Biomedical Science and Engineering, 2009, 2, 123-127 1 Bioinformatics analysis and characteristics of envelop glycoprotein E epitopes of dengue virus 1 1 1 1 1 Hua Zhong , Wei Zhao , Liang Peng , Shan-Feng Li , Hong Cao 1Department of Microbiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China. Corre- spondence should be addressed to Hong Cao (gzhcao@), Tel.:+86 20 Received Sep. 4th, 2008; revised Dec. 22nd, 2008; accepted Jan. 8th, 2009 ABSTRACT family, is a mosquito-borne human pathogen that causes dengue and dengue hemorrhagic fever which is currently The major envelope glycoprotein E of dengue one of the serious public health threats throughout the (DEN) virus plays a central role in the biology of tropical and subtropical regions of the world [1]. Four flaviviruses. It is capable of inducing a protective serotypes of DEN virus have been identified (DEN-1, 2, immune response in vivo and responsible for the 3 and 4), and each of these serotypes can infect humans viral binding to the cellular receptor. The crystal and cause disease. This virus shares many characteristics structures of glycoprotein E ectodomains have with other flaviviruses, having a single-stranded RNA already been determined. However, it