原创力文档bone loss after allogeneic haematopoietic stem cell transplantation a pilot study on the use of zoledronic acid同种异体造血干细胞移植后骨丢失一个试点研究,每年使用次唑来膦酸.pdfVIP
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bone loss after allogeneic haematopoietic stem cell transplantation a pilot study on the use of zoledronic acid同种异体造血干细胞移植后骨丢失一个试点研究,每年使用次唑来膦酸
Hindawi Publishing Corporation
Chemotherapy Research and Practice
Volume 2012, Article ID 858590, 7 pages
doi:10.1155/2012/858590
Clinical Study
Bone Loss after Allogeneic Haematopoietic Stem Cell
Transplantation: A Pilot Study on the Use of Zoledronic Acid
Andreas Hausmann,1 Wolfgang Hill,1 Hans Joachim Stemmler,1
Georg Ledderose,2 Andrea Baur-Melnyk,1 Susanne Fritsch,1 Johanna Ullmann,1
Hans-Jochem Kolb,1 Sandra Geiger,1 and Johanna Tischer1
1 Medical Department III, Ludwig-Maximilians University of Munich, Campus Großhadern, 81377 Munich, Germany
2 Department of Radiology, Ludwig-Maximilians University of Munich, Campus Großhadern, 81377 Munich, Germany
Correspondence should be addressed to Hans Joachim Stemmler, joachim.stemmler@med.uni-muenchen.de
Received 19 December 2011; Accepted 7 February 2012
Academic Editor: Piero Picci
Copyright © 2012 Andreas Hausmann et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Purpose. Bone loss is a common phenomenon following allogeneic haematopoietic stem cell transplantation (allo-HSCT). The
study aimed on tolerance and efficacy of zoledronic acid (ZA) in patients after allo-HSCT. Methods. 40 patients’ with osteoporosis
or osteopenia were recruited on this phase II study. ZA was given at a dose of 4 mg IV every 3 months for 2 years (yrs). BMD was
determined by dual-energy X-ray absorptiometry (LS lumbar spine, FH femur hip). Patients were evaluated for deoxypyridinoline
(Dpd) and calcium excretion by longitudinal measurements. Results. 36 patients who had received at least 3 doses of ZA were
evaluable. 26 patients had at least two BMD measurements sin
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