cd4+t cells differentiation and functionscd4 + t细胞分化和功能.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 925135, 12 pages doi:10.1155/2012/925135 Review Article CD4+T Cells: Differentiation and Functions Rishi Vishal Luckheeram,1, 2 Rui Zhou,1, 2, 3 Asha Devi Verma,4 and Bing Xia1, 2, 3, 5 1 Department of Gastroenterology, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan 430071, China 2 Center for Clinical Study of Intestinal Diseases, Zhongnan Hospital, Wuhan University School of Medicine, Wuhan 430071, China 3 Key Laboratory of Allergy and Immune-Related Diseases, Wuhan University School of Medicine, Wuhan 430071, China 4 Department of Paediatrics, Renmin Hospital, Wuhan University School of Medicine, Wuhan 430071, China 5 Clinical Centre of Intestinal and Colorectal diseases, Hubei, Wuhan 430071, China Correspondence should be addressed to Bing Xia, bingxia2004@ Received 14 October 2011; Revised 12 December 2011; Accepted 26 December 2011 Academic Editor: Niels Olsen Saraiva Camara Copyright © 2012 Rishi Vishal Luckheeram et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. + + CD4 T cells are crucial in achieving a regulated effective immune response to pathogens. Naive CD4 T cells are activated after interaction with antigen-MHC complex and differentiate into specific subtypes depending mainly on the cytokine milieu of the microenvironment. Besides the classical T-helper 1 and T-helper 2, other subsets have been identified, including T-helper 17, regulatory T cell,