cd4 t-cell-independent antibody response reduces enterovirus 71 lethality in mice by decreasing tissue viral loadscd4 t-cell-independent抗体反应降低小鼠的肠道病毒71杀伤力减少组织病毒载量.pdfVIP

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cd4 t-cell-independent antibody response reduces enterovirus 71 lethality in mice by decreasing tissue viral loadscd4 t-cell-independent抗体反应降低小鼠的肠道病毒71杀伤力减少组织病毒载量.pdf

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cd4 t-cell-independent antibody response reduces enterovirus 71 lethality in mice by decreasing tissue viral loadscd4 t-cell-independent抗体反应降低小鼠的肠道病毒71杀伤力减少组织病毒载量

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 580696, 9 pages doi:10.1155/2012/580696 Research Article CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads Li-Chiu Wang,1 Chia-Min Kao,2 Pin Ling,2 Ih-Jen Su,3 Tung-Miao Chang,4 and Shun-Hua Chen1, 2, 5 1 Institute of Basic Medical Sciences, Medical College, National Cheng Kung University, Tainan 701, Taiwan 2 Department of Microbiology and Immunology, Medical College, National Cheng Kung University, Tainan 701, Taiwan 3 National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Tainan 701, Taiwan 4 Statistical Analysis Laboratory, Department of International Business Management, Tainan University of Technology, Tainan 701, Taiwan 5 Center of Excellence for Infectious Diseases and Signaling Research, National Cheng Kung University, Tainan 701, Taiwan Correspondence should be addressed to Shun-Hua Chen, shunhua@.tw Received 15 March 2012; Revised 9 September 2012; Accepted 10 September 2012 Academic Editor: David Kaplan Copyright © 2012 Li-Chiu Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Enterovirus 71 (EV71) has induced fatal encephalitis in hundreds of thousands of infants and young children in the Asia-Paciﬁc region since the past decade. Lymphocyte and antibody responses have been suspected to aggravate EV71-induced neurological symptoms, so anti-inﬂammatory agents have been used to treat patients with neurological symptoms. In the present study, we found that mice deﬁcient in CD4+