changes in protein tyrosine phosphatase activity in spontaneously diabetic torii (sdt) rats蛋白质酪氨酸磷酸酶活性的变化自发糖尿病鸟居(sdt)老鼠.pdfVIP

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changes in protein tyrosine phosphatase activity in spontaneously diabetic torii (sdt) rats蛋白质酪氨酸磷酸酶活性的变化自发糖尿病鸟居(sdt)老鼠.pdf

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changes in protein tyrosine phosphatase activity in spontaneously diabetic torii (sdt) rats蛋白质酪氨酸磷酸酶活性的变化自发糖尿病鸟居(sdt)老鼠

Vol.2, No.4, 253-257 (2012) Open Journal of Animal Sciences /10.4236/ojas.2012.24035 Changes in protein tyrosine phosphatase activity in Spontaneously Diabetic Torii (SDT) rats 1 1* 1 1 2 Takayuki Yamaguchi , Takeshi Ohta , Hisayo Morinaga , Takahiro Hata , Eimei Sato , Mutsuyoshi Matsushita1 1Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., Osaka, Japan; * Corresponding Author: takeshi.ota@ 2Laboratory of Animal Reproduction, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan Received 8 August 2012; revised 13 September 2012; accepted 24 September 2012 ABSTRACT the balance of activities of phosphotyrosine kinases and phosphotyrosine phosphatases (PTPase). It has been The Spontaneously Diabetic Torii (SDT) rat is a speculated that a specific PTPase is involved in the nonobese type 2 diabetic model, showing the dephosphorylation and inactivation of IR, thus attenuat- overt hyperglycemia after about 16 weeks of age. ing insulin signaling, and disequilibrium between IR and In this study, we investigated the protein tyro- the PTPase could be a contributing factor to the insulin sine phosphatase (PTPase) activities in insu- resistance observed in type 2 diabetes mellitus [6-8]. lin-sensitive tissues in SDT rats. PTPase activi- The Spontaneously Diabetic Torii (SDT) rat is a model ties in the liver, muscle, and fat were examined for