原创力文档ca (ii)-edta shows antimicrobial activity against periodontopathic bacteriaca(ii)edta显示对periodontopathic细菌抗菌活性.pdfVIP
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ca (ii)-edta shows antimicrobial activity against periodontopathic bacteriaca(ii)edta显示对periodontopathic细菌抗菌活性
J. Biomedical Science and Engineering, 2012, 5, 10-14 JBiSE
/ 10.4236/jbise.2012.51002 Published Online January 2012 (http://www.SciRP.org/journal/jbise/)
Ca (II)-EDTA shows antimicrobial activity against
periodontopathic bacteria
Tadashi Miura, Koji Tanabe, Masao Yoshinari
Division of Oral Implants Research, Oral Health Science Center, Tokyo Dental College, Chiba, Japan
Email: tamiura@tdc.ac.jp
Received 18 October 2011; revised 28 November 2011; accepted 7 December 2011
ABSTRACT are to be prevented. Research at our laboratory has fo-
cused on developing a system of defense against infec-
Ethylenediamine-N,N,N’,N’-tetraacetic acid calcium
tion on dental material surfaces [5]. Decreasing plaque
(II) disodium salt (Ca (II)-EDTA) was investigated
accumulation has been emphasized in the prevention of
for its antibacterial activity against the periodontal
periodontal disease, including peri-implantitis [6]. An-
pathogens Aggregatibacter actinomycetemcomitans, Pre-
timicrobial materials may offer a means of reducing the
votella intermedia and Porphyromonas gingivalis. We
oral bacteria involved in the development of oral disease.
determined the minimum inhibitory concentrations
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