caenorhabditis elegans—applications to nematode genomics秀丽隠elegans-applications线虫基因组学.pdfVIP

Comparative and Functional Genomics Comp Funct Genom 2003; 4: 194–202. Published online 1 April 2003 in Wiley InterScience (). DOI: 10.1002/cfg.260 Featured Organism Caenorhabditis elegans — applications to nematode genomics William F. Gregory* and John Parkinson Institute of Cell, Animal and Population Biology, Kings Buildings, West Mains Rd, Edinburgh EH9 3JT, UK *Correspondence to: Abstract William F. Gregory, Institute of Cell, Animal and Population The complete genome sequence of the free-living nematode Caenorhabditis elegans Biology, Kings Buildings, West was published 4 years ago. Since then, we have seen great strides in technologies that Mains Rd, Edinburgh EH9 seek to exploit this data. Here we describe the application of some of these techniques 3JT, UK. and other advances that are helping us to understand about not only the biology of E-mail: b.gregory@ed.ac.uk this important model organism but also the entire phylum Nematoda. Copyright  2003 John Wiley Sons, Ltd. Received: 28 January 2003 Keywords: nematode; genome; Caenorhabditis elegans; Caenorhabditis briggsae ; Accepted: 30 January 2003 RNAi; parasites; functional genomics Background of organisms occupying a diverse set of habitats, from obligate parasites of many forms of life, Caenorhabditis elegans is a free-living soil nema- including plants, arthropods, fish and mammals to tode which has been developed as a model meta- free-living organisms occupying niches such as soil zoan for over three decades (Brenner, 1974), work and marine environments. It is interesting to note that