comparison and optimization of different methods for the in vitro production of plasmodium falciparum gametocytes不同方法的比较和优化体外生产的恶性疟原虫配子体.pdfVIP

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comparison and optimization of different methods for the in vitro production of plasmodium falciparum gametocytes不同方法的比较和优化体外生产的恶性疟原虫配子体.pdf

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comparison and optimization of different methods for the in vitro production of plasmodium falciparum gametocytes不同方法的比较和优化体外生产的恶性疟原虫配子体

Hindawi Publishing Corporation Journal of Parasitology Research Volume 2012, Article ID 927148, 7 pages doi:10.1155/2012/927148 Research Article Comparison and Optimization of Different Methods for the In Vitro Production of Plasmodium falciparum Gametocytes ´ ´ 1 1 2 1 Marıa Roncales, Jaume Vidal-Mas, Didier Leroy, and Esperanza Herreros 1 Malaria Discovery Performance Unit, GlaxoSmithKline RD, Tres Cantos Medicine Development Campus, C/Severo Ochoa No. 2, Tres Cantos, 28760 Madrid, Spain 2 Medicines for Malaria Venture. 20, route de Pre-Bois. 1215 Geneva 15, Switzerland ` ´ ´ Correspondence should be addressed to Marıa Roncales, maria.p.roncales@ and Esperanza Herreros, esperanza.a.herreros@ Received 3 October 2011; Revised 15 December 2011; Accepted 28 December 2011 Academic Editor: Xin-zhuan Su ´ ´ Copyright © 2012 Marıa Roncales et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The generation of sexually committed parasites (gametocytogenesis) is poorly understood in malaria. If the mechanisms regulating this process were elucidated, new opportunities for blocking malaria transmission could be revealed. Here we compare several methods described previously for the in vitro production of Plasmodium falciparum gametocytes. Our approach relies on the combination of several f