原创力文档constant daily hypoxia leads to different degrees of pulmonary hypertension in two different rat strains持续每日缺氧会导致不同程度的在两个不同的大鼠肺动脉高压压力.pdfVIP
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constant daily hypoxia leads to different degrees of pulmonary hypertension in two different rat strains持续每日缺氧会导致不同程度的在两个不同的大鼠肺动脉高压压力
Open Journal of Molecular and Integrative Physiology, 2012, 2, 87-92 OJMIP
/10.4236/ojmip.2012.23012 Published Online August 2012 (http://www.SciRP.org/journal/ojmip/)
Constant daily hypoxia leads to different degrees of
pulmonary hypertension in two different rat strains
*
Chadi E. Bouserhal , Erik van Lunteren, Frank J. Jacono, Kingman P. Strohl
Division of Pulmonary, Critical Care and Sleep Medicine, Louis Stokes Cleveland Department of Veterans Affairs Medical Center,
University Hospitals Case Medical Center and Case Western Reserve University, Cleveland, USA
*
Email: cserhal@
Received 14 April 2012; revised 29 May 2012; accepted 17 June 2012
ABSTRACT degree of pulmonary hypertension in these diseases may
be low, it carries important prognostic information in that
Pulmonary diseases associated with diurnal hypoxe-
its presence infers a much worse prognosis than its ab-
mia are known to be associated with pulmonary hy-
sence [5]. A genetic contribution to the pulmonary hy-
pertension in some patients. In this study we exam-
pertension phenotype in these diseases is not clear. Ge-
ined the effects of daily hypoxia (10% oxygen; 8h/day
netic predisposition is however clearly present in human
for 14 days) on two strains of rats to simulate sleep
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