correlation of psa density to prostate cancer based on prostate volume by 3.0 t mripsa密度的相关性前列腺癌基于前列腺体积的3.0 t磁共振成像.pdfVIP

Open Journal of Urology, 2011, 1, 28-36 doi:10.4236/oju.2011.13008 Published Online August 2011 (http://www.SciRP.org/journal/oju) Correlation of PSA Density to Prostate Cancer Based on Prostate Volume by 3.0 T MRI 1* 2,3 1 1 Rulon L. Hardman , Yuanyuan Liang , Steve Ware , Adam J. Jung, Qi Peng , Fadi El-Merhi1 2 3 , Yumin Chen , Ian M. Thompson 1 Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, USA 2Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, San Antonio, USA 3Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, USA E-mail : Hardmanr@ Received March 1, 2011; revised May 13, 2011; accepted June 20, 2011 Abstract Purpose: Prostate specific antigen levels can be normalized by the prostate volume to give a prostate specific antigen density (PSAd). Magnetic resonance imaging (MRI) can more accurately determine prostate zonal anatomy and prostate volumes compared to transrectal ultrasound, and hence may lead to more accurate PSAd measurements. Methods: Imaging and pathology of men undergoing prostate MRI from April 2007 to May 2009 were reviewed in this retrospective study. 73 patients were included for analysis, of which 45 had prostate cancer and 28 did not have cancer. Total, transitional zone, and pe