decreased bone mineral density in young male veterans on pioglitazone骨矿物质密度降低吡格列酮在年轻男性退伍军人.pdfVIP

Vol.2, No.1, 35-39 (2012) Journal of Diabetes Mellitus /10.4236/jdm.2012.21006 Decreased bone mineral density in young male * veterans on Pioglitazone 1# 2 3 Subhashini Yaturu , Jared Davis , Runhua Shi 1Section of Endocrinology and Metabolism, Stratton VA Medical Center, New York, USA; #Corresponding Author: Subhashini.Yaturu@; yaturu@ 2Overton Brooks VA Medical Center, East Stoner, Shreveport, USA; Jared.Davis@ 3Fiest-Weiler Cancer Center, Louisiana State University Health Sciences Center (LSUHSC), Shreveport, USA; RShi@ Received 7 December 2011; revised 12 January 2012; accepted 27 January 2012 ABSTRACT jor public health burdens. Subjects with DM have a higher risk of hip fractures [1-6] as well as fractures at Background and Objective: Epidemiological and other sites [5,7,8]. Hip fractures are associated with sig- observational studies indicate that thiazolidin- nificant morbidity and mortality and result in increased edione (TZD) therapy with rosiglitazone and health care costs [9]. Thiazolidinediones (TZDs) are an Pioglitazone is associated with an increased risk important class of insulin-sensitizing antidiabetic agents, of fractures. The effect of TZDs on bone mineral with a plethora of beneficial effects in addition to im- density (BMD) in men with type 2 diabetes is still