diffuse large b-cell lymphoma with anaplastic clear cells a rare variant弥漫型大b细胞淋巴瘤与未分化细胞一种罕见的变异.pdfVIP

Open Journal of Pathology, 2012, 2, 150-154 1 Published Online October 2012 (http://www.SciRP.org/journal/ojpathology) /10.4236/ojpathology.2012.24028 Diffuse Large B-Cell Lymphoma with Anaplastic Clear Cells: A Rare Variant 1* 1 2 Mónica Belinda Romero-Guadarrama , Leslie Elizmara Aguilar-Ayala , German Ott , Jorge Pérez-Espinosa1 1Unit Pathology, Hospital General de México, OD and Medicine School, Autonomous National University of Mexico, Mexico City, Mexico; 2Department of Clinical Pathology, Robert-Bosch-Hospital, Stuttgart, Germany. * Email: monicaromero@.mx Received June 20th, 2012; revised July 26th, 2012; accepted August 6th, 2012 ABSTRACT Introduction: Diffuse Large B-Cell Lymphoma (DLBCL) is a heterogeneous group conformed by morphological and clinical varieties of neoplasms; it originates from peripheral B-cells and is distinguished into three groups: germinal center (GC), activated B lymphocyte (ABL), and the third type. The existence of DLBCL with anaplastic morphology and expression of CD30 without t (2, 5) translocation is rare. The aim of the present article is to describe this morphol- ogic variant in a 54-year-old woman and a 74-year-old man, respectively. Materials and Methods: Patients diagnosed with DLBCL with anaplastic variant were identified from the surgical pathology records. Results: Out of 357 biopsies with this diagnosis, 11 (3%) corresponded to the anaplastic variant, 2 presented morphological clear cells; they became visible because of an increase in volume in the cervical area of 4 months of evolution, usually associated to diaphoresis and weight loss with clinical fulminating progression. An autopsy study was performed to one patient and it showed in