原创力文档disruption of drug effects (dopamine, nicotine, pilocarpine, κ-opioid) in planarians by uv light破坏的药物效果(多巴胺、尼古丁、毛果芸香碱,κ-opioid)真涡虫的紫外线.pdfVIP
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disruption of drug effects (dopamine, nicotine, pilocarpine, κ-opioid) in planarians by uv light破坏的药物效果(多巴胺、尼古丁、毛果芸香碱,κ-opioid)真涡虫的紫外线
Pharmacology Pharmacy, 2012, 3, 358-363
/10.4236/pp.2012.33048 Published Online July 2012 (http://www.SciRP.org/journal/pp)
Disruption of Drug Effects (Dopamine, Nicotine,
Pilocarpine, -Opioid) in Planarians by UV Light
1* 1 1 1 1
Robert B. Raffa , Christopher S. Tallarida , Aruj Choudhry , Nadia Sanni-Adam , Sean McGonigle ,
Michael Baron1 1 2,3 2,3
, Zhuo L. Chen , Scott M. Rawls , Ronald J. Tallarida
1Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, USA; 2Department of Phar-
macology, Temple University School of Medicine and Center for Substance Abuse Research, Temple University, Philadelphia,
USA.
*
Email: robert.raffa@
Received March 14th, 2012; revised April 25th, 2012; accepted May 11th, 2012
ABSTRACT
Based on previous work, it has been hypothesized that the energetics of ultraviolet (UV) light disrupts effects induced
by receptor-binding ligands. If this hypothesis is true, then UV light should 1) disrupt a broad variety of endpoints and 2)
disrupt effects produced by ligands that bind to diverse receptor types. This was tested directly in the present study by
using ligands selective for four different receptors (one ionotropic, three metabotropic) and three different behavioral
endpoints. The selective dopamine D2 receptor antagonist (–)sulpiride (0.1 M) dose-relatedly decreased spontaneous
locomotor velocity, the selective nicotinic acetylcholine receptor agonist nicotine (1, 3, 5 mM) and the selective mus-
carinic acetylcholine receptor agonist pilocarpine (20, 30, 50 mM) induced seizure-like activity, and the selective
-opioid receptor agonist U-50,488H (10 M) produced physic
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