原创力文档diffuse large b-cell lymphoma of the central nervous system. immunophenotype, clinicopathological features and differential diagnosis弥漫型大b细胞淋巴瘤的中枢神经系统。.pdfVIP
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diffuse large b-cell lymphoma of the central nervous system. immunophenotype, clinicopathological features and differential diagnosis弥漫型大b细胞淋巴瘤的中枢神经系统。
Open Journal of Pathology, 2012, 2, 133-139 1
Published Online October 2012 (http://www.SciRP.org/journal/ojpathology)
/10.4236/ojpathology.2012.24024
Diffuse Large B-Cell Lymphoma of the Central Nervous
System. Immunophenotype, Clinicopathological Features
and Differential Diagnosis
1* 1
Mónica Belinda Romero-Guadarrama , María Esther Gutiérrez Díaz-Ceballos ,
Fiacro Jiménez-Ponce2, Samantha Thingen-Velarde3
1 2
Unit Pathology Hospital General de México, Medicine School, Autonomous University of Mexico, Mexico City, Mexico; Neurosur-
gery Unit Hospital General de México, Mexico City, Mexico; 3Hemathology Service, Hospital General de México, Mexico City, Mexico.
*
Email: monicaromero@.mx
Received June 14th, 2012; revised July 12th, 2012; accepted July 23rd, 2012
ABSTRACT
Background: Diffuse large B-cell lymphomas of the central nervous system (DLBCL CNS) represent less than 1% of
all lymphomas and between 2% and 3% of all cerebral tumors. They occur in adults of 60 years of age or more. The
objective of this work is to describe the clinical-pathological characteristics, the immunophenotype and the differential
diagnosis. Clinical Case: From the files of the surgical pathology unit we found four cases of primary diffuse large B
cell lymphoma of the central nervous system in a 6-year period. Three corresponded to women over 47 years of age and
the other to a 42-year-old man. The time of evolution was between 2 and 4 months. The symptoms were headache,
blurred vision, hemiparesis, and seizures. Localization was in the pineal region, the frontal, parietal regions, and the
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