原创力文档dose-dependent effect of parathyroid hormone 1-34 fragment and its influence mechanism on the functional activity of isolated heart剂量依赖性的影响甲状旁腺激素猴片段及其影响机制的功能活动孤立的心.pdfVIP
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dose-dependent effect of parathyroid hormone 1-34 fragment and its influence mechanism on the functional activity of isolated heart剂量依赖性的影响甲状旁腺激素猴片段及其影响机制的功能活动孤立的心
Open Journal of Molecular and Integrative Physiology, 2012, 2, 44-49 OJMIP
/10.4236/ojmip.2012.22007 Published Online May 2012 (http://www.SciRP.org/journal/ojmip/)
Dose-dependent effect of parathyroid hormone 1-34
fragment and its influence mechanism on the functional
activity of isolated heart
1 1 2 1
Anna S. Ter-Markosyan , Knarik R. Harutunyan , Rafik Sh. Sargsyan , Drastamat N. Khudaverdyan
1Department of Physiology, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia
2Laboratory of Integrative Biology, Physiology Institute after L. A. Orbeli of RA NAS, Yerevan, Armenia
Email: annasmark@
Received 16 March 2012; revised 11 April 2012; accepted 5 May 2012
ABSTRACT 1. INTRODUCTION
The present investigation is the continuation of our In recent years, particular attention is paid to the role of
prior clinical studies on the content of parathyroid calcium-regulating system of the organism (parathyroid
hormone (PTH), its paracrine analog, parathyroid hormone (PTH), calcitonin, parathyroid hormone-related
hormone-related protein (PTHrP) and electrolytes in peptide (PTHrP)) in the mechanism of pacemaker mani-
blood of patients with heart failure. The results of festation and heart contractile activity [1], blood pressure
these studies formed the basis for the nomination of regulation [2-7], renal system functioning [8], prolifera-
the hypothesis on PTH and PTHrP compensatory- tion and functioning of different structures [9], in par-
modulating effect on the contractile activity of heart.
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