down regulation of survivin gene and up regulation of p53 gene expression by sirna induces apoptosis in human hepatocellular carcinoma cell line hepg2生存素基因的调控和监管的p53基因表达的sirna hepg2人类肝癌细胞发生凋亡.pdfVIP

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down regulation of survivin gene and up regulation of p53 gene expression by sirna induces apoptosis in human hepatocellular carcinoma cell line hepg2生存素基因的调控和监管的p53基因表达的sirna hepg2人类肝癌细胞发生凋亡.pdf

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down regulation of survivin gene and up regulation of p53 gene expression by sirna induces apoptosis in human hepatocellular carcinoma cell line hepg2生存素基因的调控和监管的p53基因表达的sirna hepg2人类肝癌细胞发生凋亡

J. Biomedical Science and Engineering, 2009, 2, 57-62 1 Down regulation of surviving gene and up regulation of p53 gene expression by siRNA induces apoptosis in human hepatocellular carcinoma cell line HepG2 Yun-Hua Lu 1,2,3, Cong Tang 1,2 , Wei Wang 1,2, Tao Xi 1,2* 1Research Centre of Biotechnology, China Pharmaceutical University, NanJing, 210009, China. 2JiangSu Key Laboratory of Carcinogenesis and intervention, China Pharmaceutical University. 3School of Chemistry Biotechnology, YiChun University, YiChun, JiangXi, 33600, China. *Correspondence should be addressed to Yun-Hua Lu (lyh655@) th st st Received April 16 , 2008; revised October 31 , 2008; accepted October 31 , 2008 ABSTRACT inhibition of apoptosis. It was selectively overexpressed in the majority of human tumor types including liver, Survivin gene may be a good target for cancer lung, breast, colon, hepatocellular, oesophageal, pancreatic, gene therapy because it is over expressed in a bladder, uterine and ovarian cancers, largecell non- variety of human tumors including human Hodgkin’s lymphomas, leukaemias, neuroblastoma, 9 hepatocellular carcinoma but not in differen- brain tumors, pheochromocytoma, soft tissue sarcomas, 0 tiated adult tissues. To explore the effects of the melanomas and other skin cancer, but not in adult dif- 0