不同茎叶比例的穿心莲药材中穿心莲内酯与脱水穿心莲内酯的-药学学报.PDFVIP

药学学报 Acta Pharmaceutica Sinica 2010, 45 (5) : 673676 ·673 · ·研究简报· 不同茎叶比例的穿心莲药材中穿心莲内酯与脱水穿心莲内酯 的X 射线衍射定量分析方法的探讨 龚宁波, 吕丽娟, 刘 超, 马 林, 陈若芸, 吕 扬* ( 中国医学科学院、北京协和医学院 物研究所, 北京 100050) 关键词: 穿心莲中药材; 穿心莲内酯; 脱水穿心莲内酯; 粉末X 射线衍射; 定量分析 中图分类号: R917 文献标识码:A 文章编号: 05 13-4870 (2010) 05-0673-04 A quantitation method for andrographolide and dehydroandrographolide by X-ray powder diffraction Fourier fingerprint pattern technique * GONG Ning-bo, L Li-juan, LIU Chao, MA Lin, CHEN Ruo-yun, L Yang (Institute of Materia Medica, Chinese Academy of M edical Sciences Peking Union M edical College, Beij ing 100050, China) Abstract: The powder X-ray diffraction Fourier fingerprint pattern technique was used to develop a new quantitation method for the analysis of andrographolide and dehydroandrographolide. And the high performance liquid chromatography method was used to evaluate the quantity of andrographolide and dehydroandrographolide. The relationship of diffraction peak intensity and content of andrographolide and dehydroandrographolide was investigated. The powder X-ray diffraction Fourier fingerprint pattern analysis technique can be used to evaluate the quantity of andrographolide and dehydroandrographolide in the herb simultaneously. Key words: Herba andrographitis; andrographolide; dehydroandrographolide; powder X-ray diffraction analysis; quantitative analysis 穿心莲中 材为爵床科植物穿心莲Andrograp his 脱水穿心莲内酯成分研究, 获得它们特征性衍射数 pan iculata (Burm. f.) Nees 的干燥地上部分。秋初茎 据; 利用高效液相色谱 (HPLC) 技术对不同茎叶比 叶茂盛时采割, 晒干。性味苦、寒, 归心、肺、大肠、 例穿心莲中药