effect of atypical antipsychotics on fetal growth is the placenta involved非典型抗精神病药物对胎儿生长的影响是胎盘.pdfVIP

Hindawi Publishing Corporation Journal of Pregnancy Volume 2012, Article ID 315203, 9 pages doi:10.1155/2012/315203 Review Article Effect of Atypical Antipsychotics on Fetal Growth: Is the Placenta Involved? Sandeep Raha,1 Valerie H. Taylor,2 and Alison C. Holloway3 1 Department of Pediatrics, McMaster University, 1200 Main Street West, Room 3N11, Hamilton, ON, Canada L8N 3Z5 2 Department of Psychiatry, Women’s College Research Institute, University of Toronto, Toronto, ON, Canada M5S 1B1 3 Department of Obstetrics and Gynecology, McMaster University, 1200 Main Street West, Room 3N52, Hamilton, ON, Canada L8N 3Z5 Correspondence should be addressed to Sandeep Raha, rahas@mcmaster.ca Received 3 April 2012; Accepted 18 June 2012 Academic Editor: Timothy Regnault Copyright © 2012 Sandeep Raha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. There is currently considerable uncertainty regarding prescribing practices for pregnant women with severe and persistent psychi- atric disorders. The physician and the mother have to balance the risks of untreated psychiatric illness against the potential fetal toxicity associated with pharmacological exposure. This is especially true for women taking atypical antipsychotics. Although these drugs have limited evidence for teratological risk, there are reports of altered fetal growth, both increased and decreased, with maternal atypical antipsychotic use. These effects may be mediated through changes in the maternal metabolism which in turn impacts placental function. However, the presence of receptors targeted by atypical antipsychotics in cell lineages present in the