effect of unilateral low-frequency stimulation of hippocampus on rapid kindling—induced seizure development in rats单方面的影响低频刺激海马在老鼠kindling-induced发作迅速发展.pdfVIP

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effect of unilateral low-frequency stimulation of hippocampus on rapid kindling—induced seizure development in rats单方面的影响低频刺激海马在老鼠kindling-induced发作迅速发展.pdf

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effect of unilateral low-frequency stimulation of hippocampus on rapid kindling—induced seizure development in rats单方面的影响低频刺激海马在老鼠kindling-induced发作迅速发展

Neuroscience Medicine, 2012, 3, 174-180 /10.4236/nm.2012.32022 Published Online June 2012 (http://www.SciRP.org/journal/nm) Effect of Unilateral Low-Frequency Stimulation of Hippocampus on Rapid Kindling—Induced Seizure Development in Rats Lucas Toibaro, Magdalena Pereyra, Julieta Pastorino, Ariela Smigliani, Florencia Ocariz, * Germán Ortmann, María Milagros Galardi, María Belén Gori, Silvia Kochen Epilepsy Laboratory, Institute of Cellular Biology and Neuroscience—National Council for Scientific and Technical Research (CONICET), School of Medicine, University of Buenos Aires, Buenos Aires, Argentina. * Email: skochen@retina.ar Received February 10th, 2012; revised March 13th, 2012; accepted April 5th, 2012 ABSTRACT Since the last decade deep brain stimulation has been proposed as an alternative treatment for patients who do not be- come seizure-free with the current pharmacological treatments and cannot undergo resective surgical procedure. How- ever, the optimal stimulation parameters remain undetermined and active research in humans and animals is necessary. The present study was designed to investigate the effect of unilateral Low Frequency Stimulation (LFS) of hippocam- pus on seizure development by using the hippocampal rapid kindling method (hRK) in rats. We used male Wistar rats implanted with electrodes in the ventral hippocampus. All rats underwent hRK (biphasic square wave pulses, 20 Hz for 10 seconds) during three consecutive days (twelve stimulations per day). The control group (hRK; n = 6) received only RK stimulus, while the treated group (LFS-hRK; n = 8) received also LFS (biphasic square wave pulses, 1 Hz for 30 seconds) immediately before the RK stimulus, during three consecutive days. At the end of behavioral testing on day 3, 62% (P 0.05) of the animals receiving LFS treatment