effect of dietary conjugated linoleic acid supplementation on early inflammatory responses during cutaneous wound healing补充膳食共轭亚油酸对早期炎症反应在皮肤伤口愈合.pdfVIP

Hindawi Publishing Corporation Mediators of Inflammation Volume 2010, Article ID 342328, 8 pages doi:10.1155/2010/342328 Research Article Effect of Dietary Conjugated Linoleic Acid Supplementation on Early Inflammatory Responses during Cutaneous Wound Healing Na-Young Park, Giuseppe Valacchi, and Yunsook Lim Department of Food and Nutrition, Research Institute of Science for Human Life, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-761, Republic of Korea Correspondence should be addressed to Yunsook Lim, ylim@khu.ac.kr Received 22 January 2010; Accepted 6 July 2010 Academic Editor: Chiara De Luca Copyright © 2010 Na-Young Park et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Inflammatory response is considered the most important period that regulates the entire healing process. Conjugated linoleic acid (CLA), a class of linoleic acid positional and geometric isomers, is well known for its antioxidant and anti-inflammatory properties. We hypothesized that dietary CLA supplementation accelerates cutaneous wound healing by regulating antioxidant and anti-inflammatory functions. To investigate wound closure rates and inflammatory responses, we used a full-thickness excisional wound model after 2-week treatments with control, 0.5%, or 1% CLA-supplemented diet. Mice fed dietary CLA supplementation had reduced levels of oxidative stress and inflammatory markers. Moreover, the wound closure rate was improved significantly in mice fed a 1% CLA-supplemented diet during early stage of wound healing (inflammatory stage). We conclude that dietary CLA supplementation enhances the early stage of cutaneous woun