effects of 16-week consumption of caffeinated and decaffeinated instant coffee on glucose metabolism in a randomized controlled trial16周的影响食用含咖啡因和不含咖啡因的咖啡,在葡萄糖代谢的随机对照试验.pdfVIP

Hindawi Publishing Corporation Journal of Nutrition and Metabolism Volume 2012, Article ID 207426, 9 pages doi:10.1155/2012/207426 Research Article Effects of 16-Week Consumption of Caffeinated and Decaffeinated Instant Coffee on Glucose Metabolism in a Randomized Controlled Trial Keizo Ohnaka,1 Mizuko Ikeda,2 Takako Maki,2 Tomoko Okada,3 Takao Shimazoe,3 Masahiro Adachi,4 Masatoshi Nomura,4 Ryoichi Takayanagi,4 and Suminori Kono2 1 Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan 2 Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan 3 Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan 4 Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Higashi-ku, Fukuoka 812-8582, Japan Correspondence should be addressed to Suminori Kono, skono@phealth.med.kyushu-u.ac.jp Received 4 April 2012; Revised 9 October 2012; Accepted 9 October 2012 Academic Editor: Cindy Davis Copyright © 2012 Keizo Ohnaka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. Observational studies have shown a protective association between coffee consumption and type 2 diabetes mellitus whereas caffeine or caffeinated coffee acutely deteriorates glucose tolerance. We investigated the effects of chronic drinking of instant coffee on glucose and insulin concentrations during a 75 g oral glucose tolerance test. Methods. Overweight men with a mild-to-moderate elevation of fasting plasma glucose were randomly allocated t