effects of genetic and environmental factors and gene-environment interaction on expression variations of genes related to stroke in rat brain遗传和环境因素的影响,基因-环境相互作用相关的基因表达变化在老鼠大脑中风.pdfVIP

American Journal of Molecular Biology, 2011, 1, 87-113 AJMB doi:10.4236/ajmb.2011.12011 Published Online July 2011 (http://www.SciRP.org/journal/ajmb/). Effects of genetic and environmental factors and gene-environment interaction on expression variations of genes related to stroke in rat brain Yuande Tan1, Myriam Fornage2 1College of Life Science, Hunan Normal University, Changsha, China; 2The University of Texas Health Science Center at Houston, Brown Foundation Institute of Molecular Medicine, Houston, USA. E-mail: tanyuande@ Received 15 May 2011; revised 22 June 2011; accepted 1 July 2011. ABSTRACT a complex biological process involving obstruction of blood flow in a major cerebral vessel which leads to de- To determine if genetic and environmental (dietary) regulation of genes whose expression promotes ischemic factors and gene-environment interaction impact on neuronal death and subsequent neurological dysfunction the expression variations of genes related to stroke, [1-3]. The development of stroke in an individual is in- we conducted microarray experiments using two ho- fluenced by a number of cardiovascular risk factors in- mozygous rat strains SHRSR and SHRSP fed with cluding genetic predispositions, hypertension, smoking, high and low dietary salt levels. We obtained expres- diabetes mellitus [4] as well as by dietary salt. The im- sion data of 8779 genes and performed the ranking portance of genetic factor for stroke etiology has been analysis of microarray data. The results show that documented by