原创力文档effects of surgery and palliative chemotherapy in the treatment of colorectal liver metastasis影响手术和姑息化疗治疗大肠癌肝转移.pdfVIP
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effects of surgery and palliative chemotherapy in the treatment of colorectal liver metastasis影响手术和姑息化疗治疗大肠癌肝转移
Surgical Science, 2011, 2, 312-317
doi:10.4236/ss.2011.26066 Published Online August 2011 (http://www.SciRP.org/journal/ss)
Effects of Surgery and Palliative Chemotherapy in the
Treatment of Colorectal Liver Metastasis
Nigel Bird, Ruth Bird, Ali Majeed
Liver Research Group, Royal Hallamshire Hospital, Sheffield, UK
E-mail : n.bird@shef.ac.uk
Received May 24, 2011; revised July 8, 2011; accepted July 27, 2011
Abstract
Purpose: 1) to compare the survival of patients with colorectal liver metastases who underwent resection as
the primary treatment against patients who had chemotherapy as the primary treatment; 2) to compare the
survival in patients with recurrent inoperable liver metastases (after resection) treated with Oxaliplatin or
Irinotecan against those patients with inoperable recurrence who were treated with 5-FU. Patients and
Methods: 538 patients with colorectal liver metastases were referred to our unit between November 1997
and May 2005; 247 underwent liver resection and 291 had palliative chemotherapy. Results: only 7.8% of
non-operated patients survived for 5 years compared to 32.9% of the liver resection group. After surgery,
191 patients developed inoperable recurrent disease. These patients were treated with chemotherapy; Ox/Ir
patients had a 3 year survival of 55% compared to 32% of those who received 5-FU. Our data shows that in
patients who relapse after liver surgery, chemotherapy with Oxaliplatin or Irinotecan confers a significant
survival benefit.
Keywords: Colorectal Cancer, Liver Metastasis, Surgery, Survival, Chemotherapy
1. Introduction [6,7] with 5-year survival in the range of 25% - 40% and
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